Senior/Principal Scientist in Solid Form Selection/Preformulation Development

  • Full Time
  • US
  • 12/31/2021

Website J-STAR Research, Inc.

 

J-STAR Research, Inc. operates as a contract research organization for pharmaceutical and biotechnology companies worldwide. It offers services in the areas of custom synthesis/contract research, process and analytical research, cGMP synthesis, crystallization process development, solid form screening and selection, pre/early formulation, and drug substance-drug product coprocessing.

 

Senior/Principal Scientist in Solid Form Selection/Preformulation Development

JOB TYPE: Full-time

Location: US

 

Responsibilities:

  • Lead development activities in phase-appropriate solid form selection and physicochemical characterization, such as powder X-ray diffraction, DSC, TGA, SEM, particle size, polarized light microscopy, moisture sorption analysis, solubility, dissolution and stability assessments.
  • Map polymorph, salt and cocrystal spaces of drug substances for selection of final solid form for development.
  • Understand solid form phase mapping of drug candidates to assist in crystallization process development.
  • Develop formulations to support preclinical and Phase I studies including PK, PD, efficacy, tox studies as well as first-in-human.
  • Designs experiments, strategies and workflows to improve bioavailability of poorly soluble drug molecules through enabling technologies.
  • Interact with clients closely to make sure expectations are met in target timelines.

 

Requirement Qualifications:

  • MS or PhD in Chemistry, Pharmaceutical Science or related field.
  • 0-5 years of experience in solid form selection and preformulation development (solution, suspension, tablet, capsule, etc).
  • Good understanding of solid-state chemistry of small molecule drug substances.
  • Working knowledge of analytical techniques such as PXRD, TGA, DSC, PLM, DVS, HPLC, NMR and PSD.
  • Strong communication, organization, and planning skills.

How to Apply:

Resume can be emailed directly to: shanming.kuang@jstar-research.com.  Be sure to denote the Job Title of the position you are applying.

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